Sinha P, Fauvel NJ, Singh S, Soni N (2009) Ventilatory ratio: a simple bedside measure of ventilation.Changes in the respiratory system caused by aging generally include structural changes in the thoracic cage and lung parenchyma, abnormal findings on lung function tests, ventilation and gas exchange abnormalities, decreased exercise capacity, and reduced respiratory muscle strength. Wexler HR, Lok P (1981) A simple formula for adjusting arterial carbon dioxide tension. N Engl J Med 2:19–57īeitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A (2015) Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F, Brazzi L, Camporota L (2020) COVID-19 pneumonia: different respiratory treatments for different phenotypes? Intensive Care Med 46:1099–1102Īckermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D (2020) Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. 1C), there was no difference in the two compliance groups in estimated physiological dead space fraction (Fig. Although patients with compliance < 40 mL/cmH 2O had a higher corrected minute volume (Fig. Compared with patients with PaO 2/FiO 2 > 150 mmHg, patients with PaO 2/FiO 2 < 150 mmHg had higher estimated physiological dead space fraction (Fig. All estimates of physiological dead space increased with the degree of hypoxaemia, but not with the reduction in lung compliance (Fig. ICU outcome was available for 193 patients, where estimated physiological dead space fraction was higher in non-survivors.
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